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Discussion EpsteinBarr virus (EBV) was the first human-discovered oncogenic virus, and since its initial discovery in 1968, its threat to human health has become increasingly known 3

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Notably, in RA patients with low disease activity, a 12-week course of low-dose sirolimus (0.5 mg every other day) also exhibited a favorable safety profile, elevating Treg levels and enhancing clinical outcomes without evidence of toxicitiessuch as hemorrhagic cystitis or liver fibrosisthat are associated with certain conventional immunosuppressive agents (142)

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JAMA Psychiatry, 82(4), 395405